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. 2017 Nov 1;37(44):10567–10586. doi: 10.1523/JNEUROSCI.0758-17.2017

Figure 4.

Figure 4.

Glutamate iontophoresis drives LAT and BA neuronal firing rate more effectively in females than males. A, Representative traces of iontophoretic current applied to eject glutamate (top), the neuronal response to glutamate (middle), and a time histogram of the firing rate (Hz) of the neuron across time (bottom) in LAT neurons recorded in a female (left) and male (right) rat. B, Glutamate drove LAT neuron firing more effectively in females compared with males (p < 0.05, two-way ANOVA). C, The effectiveness of glutamate to drive LAT neurons was dependent on the estrous cycle stage, where glutamate was more effective at lower current applications in proestrous females and higher current applications were more effective in diestrous females (p < 0.05, two-way ANOVA). D, Representative traces of iontophoretic current applied to eject glutamate (top), the neuronal response to glutamate (middle), and a time histogram of the firing rate (Hz) of the neuron across time (bottom) in BA neurons recorded in a female (left) and male (right) rat. E, Glutamate drove BA neuron firing more effectively in females compared with males (p < 0.05, two-way ANOVA). F, BA neurons in proestrous females were more responsive to glutamate iontophoresis compared with diestrous females (p < 0.05, two-way ANOVA). **p < 0.05, two-way ANOVA.