Table 1.
Experimental details
| Monkey | Weight, kg | Inj. mass, μg/kg | BPND | Drug | Drug dose, μg/kg | Time of administration, min | Induction anesthetics |
|---|---|---|---|---|---|---|---|
| M1 | 10.6 | 0.70 | 2.15 | BSL | — | — | Type 1 |
| M3 | 7.4 | 0.41 | 2.04 | BSL | — | — | Type 1 |
| M2 | 11.4 | 0.13 | 2.02 | AZ | 0.88 | 55.2 | Type 1 |
| M1 | 10.6 | 0.12 | 1.91 | AZ | 0.94 | 65.5 | Type 1 |
| M1 | 10.6 | 0.27 | 2.09 | AZ | 1.89 | 52.3 | Type 1 |
| M1 | 10.6 | 0.12 | 2.07 | AZ | 2.86 | 55.0 | Type 1 |
| M3 | 7.4 | 0.25 | 1.94 | AZ | 4.05 | 62.4 | Type 1 |
| M2 | 12.0 | 0.56 | 1.74 | AZ | 4.17 | 60.0 | Type 2 |
| M3 | 10.3 | 0.34 | 1.90 | AZ | 4.85 | 59.9 | Type 2 |
| M2 | 13.8 | 0.15 | 0.88 | AZ | 5.00 | 60.0 | Type 2 |
| M2 | 13.8 | 0.14 | 0.61 | AZ | 36.20 | 40.0 | Type 2 |
| AZ | 5.00 | 60.0 | |||||
| M3 | 10.3 | 0.37 | 1.67 | Sumatriptan | 19.4 | 59.6 | Type 2 |
| M2 | 12.0 | 0.30 | 1.70 | GR127935 | 200 | 60.0 | Type 2 |
| M3 | 12.2 | 0.42 | 1.12 | GR127935 | 200 | 62.8 | Type 2 |
| M3 | 12.2 | 0.31 | n.a. | GR127935 | 500 | −14.0 | Type 2 |
| AZ | 5.00 | 60.1 |
BPND represent the baseline nondisplaceable binding potential before a challenge. BSL indicates a baseline experiment, where no challenge was given. Time of administration of the drug is relative to the injection (inj.) of the radioligand. Induction of anesthesia was performed in two ways: Type 1: diazepam (0.4 mg/kg) + ketamine (20 mg/kg); Type 2: ketamine (10 mg/kg) + xylazine (0.5 mg/kg) following reversal of xylazine with yohimbine (0.11 mg/kg).