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. 2017 Nov 1;37(44):10690–10699. doi: 10.1523/JNEUROSCI.2141-17.2017

Figure 1.

Figure 1.

CaMKII is involved in increased synaptic NMDAR activity of spinally projecting PVN neurons in SHRs. A, Representative current traces of evoked AMPAR-EPSCs (at a holding potential of −60 mV) and NMDAR-EPSCs (at a holding potential of +40 mV) recorded in labeled PVN neurons from WKY rats and SHRs treated with vehicle or 10 μm AIP. B, Summary data of evoked AMPAR-EPSCs and NMDAR-EPSCs in labeled PVN neurons recorded from WKY rats and SHRs treated with vehicle (n = 7 in the SHR group; n = 9 in the WKY group) or AIP (n = 9 in the SHR group; n = 8 in the WKY group). C, Group data show the ratio of NMDAR-EPSCs to AMPAR-EPSCs in labeled PVN neurons recorded from WKY rats or SHRs treated with vehicle or AIP. Data are presented as the mean ± SEM. One-way ANOVA with Tukey's post hoc test was used to analyze the difference in the NMDAR-EPSCs and the ratio of NMDAR-EPSCs to AMPAR-EPSCs among the four groups. *p < 0.05 compared with the values in the vehicle group in WKY rats. #p < 0.05 compared with the values in the SHR vehicle group.