Figure 2.

CaMKII contributes to the increased postsynaptic NMDAR activity of spinally projecting PVN neurons in SHRs. A, B, Original current traces (A) and summary data (B) show the effect of 10 μm AIP on puff-NMDA (100 μm)-elicited currents of labeled PVN neurons recorded from WKY rats (vehicle, n = 9; AIP, n = 9) and SHRs (vehicle, n = 8; AIP, n = 9). Data are presented as the mean ± SEM. One-way ANOVA with Tukey's post hoc test was used to analyze the difference in the NMDAR currents among the four groups. *p < 0.05 compared with the respective values in WKY rats; #p < 0.05 compared with the SHR vehicle group.