Figure 3.

CaMKII increases presynaptic NMDAR activity of spinally projecting PVN neurons in SHRs. A–D, Original traces (A, C) and cumulative probability analysis (B, D) show the effect of bath application of AP-5 (50 μm) on mEPSCs of labeled PVN neurons recorded from WKY rats (A, B) and SHRs (C, D) that were treated with vehicle or 10 μm AIP. E, F, Summary data show the effects of AIP and AP-5 on the frequency and amplitude of mEPSCs in labeled PVN neurons of WKY rats (vehicle, n = 8; AIP, n = 8) and SHRs (vehicle, n = 9; AIP, n = 9). Data are presented as the mean ± SEM. *p < 0.05 compared with the respective value in WKY rats; #p < 0.05 compared with the baseline in the SHR vehicle group.