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. 2017 Nov 1;37(44):10690–10699. doi: 10.1523/JNEUROSCI.2141-17.2017

Figure 4.

Figure 4.

CaMKII and CK2 contributes to enhanced synaptic NMDAR activity of spinally projecting PVN neurons in SHRs. A, B, Original current traces (A) and summary data (B) show the effect of AIP (10 μm) plus DRB (100 μm) on puff NMDA (100 μm)-elicited currents of labeled PVN neurons recorded from SHRs (vehicle, n = 7; AIP plus DRB, n = 8). C–F, Original traces (C, E) and cumulative probability analyses (D, F) show that DRB plus AIP decreased the basal frequency of mEPSCs of labeled PVN neurons recorded from SHRs (C, E) and eliminated the effect of AP-5 (50 μm) on the frequency of mEPSCs (E, F). G, Summary data show the effects of AIP plus DRB and AP-5 on the frequency and amplitude of mEPSCs in labeled PVN neurons of SHRs (vehicle, n = 10; AIP plus DRB, n = 10). Data are presented as the mean ± SEM. *p < 0.05 compared with the baseline in the SHR vehicle group.