Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The m6A methyltransferase METTL16 binds diverse cellular RNAs, such as pre‐mRNAs, lncRNAs and several ncRNAs including the U6 snRNA. METTL16 associates with La, LARP7 and the methylphosphate capping enzyme MEPCE and installs U6‐m6A43 during the early stages of U6 snRNP biogenesis on an oligouridylated transcript. During splicing, A43 is involved in base pairing interactions with the 5′ splice site (5′SS) of pre‐mRNAs.
