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. 2017 Oct 13;36(21):3194–3211. doi: 10.15252/embj.201797259

Figure 5. GFP‐Aub iCLIP in GSCs and targeting by piRNAs, in Cbl mRNAs.

Figure 5

  • A
    GFP‐Aub crosslinks in cultured GSCs (Ma et al, 2017), in Cbl mRNAs. Thin boxes are 5′‐ and 3′UTRs, lines are introns, and thick boxes are exons. The coverage of Cbl mRNAs with iCLIP reads is shown in blue. Significant crosslink clusters are shown in red.
  • B, C
    Sequences of crosslinked regions in 5′UTR (B) and 3′UTR (C) of CblL mRNA. The nucleotides (nt) in significant crosslink clusters are in red. The sequence, occurrence, and origin of anti‐sense piRNAs from ovarian and embryonic libraries are indicated. Mismatched nt are in blue.
  • D, E
    Coverage of CblL (D) and CblS (E) mRNAs with ovarian and embryonic piRNAs. Significant crosslink clusters are indicated in red at the top of the graphs.