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Schematic drawing of KMT2A, MLL fusions, and MLL-PTD with indicated domains. KMT2A, Lysine methyltransferase 2A; MLL, mixed-lineage leukemia; PTD, partial tandem duplication; NLS, nuclear localization signal; FYRN, FY-rich amino terminal; TAS, transcription activation domain; FYRC, FY-rich carboxyl terminal; SET, Su(Var)39, enhancer of zeste, and trithorax; AF4(9)(10), ALL1-Fused gene from chromosome 4(9)(10) protein; ENL, eleven nineteen leukemia.
