Table 1.
Top 10 most frequent genes used in mouse models listed on http://www.alzforum.org/research-models
| Gene | Associated neurodegenerative disease(s) | Number of models | Total (out of 147) (%) |
|---|---|---|---|
| APP | AD | 60 | 40.8 |
| PSEN1 | AD | 27 | 18.4 |
| MAPT | FTLD/PSP/CBD | 24 | 16.3 |
| TARDP | ALS/FTLD | 14 | 9.5 |
| APOE | AD | 10 | 6.8 |
| PSEN2 | AD | 7 | 4.8 |
| BACE1 | AD | 5 | 3.4 |
| FUS | ALS/FTLD | 5 | 3.4 |
| SOD1 | ALS | 4 | 2.7 |
| C9ORF | ALS/FTLD | 3 | 2.0 |
Groups are not mutually exclusive.
AD, Alzheimer’s disease; FTLD, frontotemporal lobar degeneration; PSP, progressive supranuclear palsy; CBD, corticobasal degeneration; ALS, amyotrophic lateral sclerosis.