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Anti-GPA33 DOTA-PRIT concept. (A) Schematic representation of anti-GPA33 BsAb huA33-C825 (left) and M-DOTA-Bn hapten (right), vehicle by which 177Lu treatment is administered. Anti-(M)-DOTA-Bn scFv antibody C825 has approximately equal low-pM affinity for either Y-DOTA-Bn or Lu-DOTA-Bn. (B) Schematic representation of 3-step anti-GPA33 DOTA-PRIT protocol. (Copyright 2016, reprinted with permission from Memorial Sloan Kettering Cancer Center [MSK].)
