Skip to main content
. 2017 Nov;58(11):1858–1864. doi: 10.2967/jnumed.116.187971

TABLE 2.

Potencies and Efficacies of Peptide Conjugates

EC50 (nM)
Agonist cAMP inhibition Receptor internalization
Ga-DOTATOC 0.02 ± 0.01 11.0 ± 0.8
Cu-DA-TOC 0.08 ± 0.07 78.3 ± 37.7
Cu-DA(IR800)-TOC 1.38 ± 0.54 455 ± 299
Cu-MMC(IR800)-TOC 0.21 ± 0.18 41.9 ± 29.8

Data are expressed as mean ± SD of the maximum possible effect for the agonist (Emax) values, which were calculated as difference between maximum and minimum signal for each analog and expressed as percentage of Emax value for internal control, Ga-DOTATOC.