Table I.
Patient characteristics and expression of HH and WNT pathway members.
| Characteristics | No. | % | P-value stage | P-value RFS | P-value OS |
|---|---|---|---|---|---|
| Stage | |||||
| 1A | 6 | 16.7 | |||
| 1B | 1 | 2.8 | |||
| 2A | 14 | 38.9 | |||
| 2B | 4 | 11.1 | |||
| 3A | 4 | 11.1 | |||
| 3B | 0 | 0.0 | |||
| 3C | 5 | 13.9 | |||
| 4 | 2 | 5.6 | 0.0055 | 0.0036 | |
| Grade | |||||
| 2 | 5 | 13.9 | |||
| 3 | 31 | 86.1 | 0.3 | 0.732 | 0.985 |
| SHH | |||||
| 1 | 8 | 22.2 | |||
| 2 | 20 | 55.6 | |||
| 3 | 8 | 22.2 | 0.0440 | 0.051 | 0.026 |
| Gli-1 | |||||
| 0 | 1 | 2.8 | |||
| 1 | 9 | 25.0 | |||
| 2 | 14 | 38.9 | |||
| 3 | 12 | 33.3 | 0.0010 | 0.0213 | 0.017 |
| Nuclear Gli-1 | |||||
| <10% | 11 | 30.6 | |||
| >10% | 25 | 69.4 | 0.0080 | 0.003 | 0.0387 |
| β-catenin | |||||
| Membranous | 13 | 36.1 | |||
| Nuclear/cytoplasmic | 23 | 63.9 | 0.0030 | 0.019 | 0.025 |
HH, Hedgehog; SHH, sonic HH; Gli-1, glioma-associated oncogene homolog-1; RFS; relapse-free survival; OS, overall survival.