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. 2017 Sep 1;14(5):5121–5128. doi: 10.3892/ol.2017.6865

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Knockdown of CCND1 has a similar effect to miR-193a-3p transfection. (A) Knockdown of miR-193a-3p by siCCND1 suppressed prostate cancer cell growth; siCCND1 induced a reduction in the viability of DU-145 and PC3 cells at 48 h post-transfection by ~18.6 and ~18.5%, respectively (*P<0.05 and **P<0.01). (B) siCCND1 reduced the colony-formation rate in DU-145 and PC3 cells (representative wells are presented) (***P<0.001). (C) siCCND1 reduced the protein expression levels of CCND1 in the cells. All data are presented as the mean + standard deviation of at least three repeated experiments (***P<0.001 vs. NC). CCND1, cyclin D1; miR, microRNA; siCCND1, small interfering RNA targeting CCND1; UTR, untranslated region; NC, negative control. (D) Knockdown of CCND1 induced a significant G₁ phase arrest (representative histograms are depicted).