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. 2017 Sep 1;14(5):5121–5128. doi: 10.3892/ol.2017.6865

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Rescued CCND1 expression reverses miR-193a-3p-induced G₁ phase arrest. (A) PC3 cells were co-transfected with miR-193a-3p mimics or NC oligonucleotides, and pCCND1 or pNull. The expression of CCND1 and GAPDH was detected by western blot analysis. (B) Independent of CCND1 transfection, miR-193a-3p causes significant G1 phase arrest (***P<0.001). (C) Flow cytometry indicated that the induced expression of CCND1 partially attenuated the cell cycle arrest in miR-193a-3p-transfected PC3 cells. All data are presented as the mean + standard deviation. CCND1, cyclin D1; miR, microRNA; NC, negative control; pNull, empty vector; pCCND1, pIRES-EGFP-CCND1.