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. 2017 Sep 1;31(17):1770–1783. doi: 10.1101/gad.305482.117

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© 2017 Zhou et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 3. — RNA-seq analysis shows that ZNF281 enhances cardiac genes and represses inflammatory genes. (A) Heat map of 1500 differentially expressed genes in 5F-treated versus 6F-treated TTFs identified by RNA-seq. (Red) Up-regulation; (blue) down-regulation. RNA-seq samples were prepared from adult TTFs reprogrammed for 7 d. (B,C) GO analysis showing biological processes associated with genes up-regulated (B) and down-regulated (C) by ZNF281. (D,E) Gene expression changes between 6F and 5F for selected cardiac markers (D) or inflammatory markers (E) as determined by RNA-seq. (F–H) Enrichment plots of the indicated gene sets and their nominal P-value of genes up-regulated by ZNF281. (I,J) Enrichment plots of the indicated gene sets and their nominal P-value of genes down-regulated by ZNF281.