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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Antiviral Res. 2017 Jun 20;145:24–32. doi: 10.1016/j.antiviral.2017.06.015

Table 1.

Anti-filovirus activities of validated compounds.

Hit ID Structure Pseudovirus
Infectious EBOV
IC50, μM
CC50, μM IC50, μM CC50, μM SI
EBOV MARV
cp3 graphic file with name nihms894870t1.jpg 6.9 ± 1.4 9.1 ± 1.0 156.9 ± 12.5 5.2 ± 0.7 223 43
cp5 graphic file with name nihms894870t2.jpg 4.1 ± 1.3 9.0 ± 1.8 >264.3 4.0 ± 0.6 264 66
cp11 graphic file with name nihms894870t3.jpg 3.8 ± 0.7 5.6 ± 0.7 74.9 ± 19.4 7.5 ± 1.3 85 11
cp13 graphic file with name nihms894870t4.jpg 6.4 ± 0.9 9.2 ± 1.7 >291.2 8.7 ± 0.9 150 17
cp15 graphic file with name nihms894870t5.jpg 1.8 ± 0.7 5.1 ± 1.6 50.3 ± 2.7 5.2 ± 0.2 80 16
cp16 graphic file with name nihms894870t6.jpg 3.8 ± 0.9 6.9 ± 0.9 77.8 ± 14.0 5.1 ± 0.1 146 28
cp19 graphic file with name nihms894870t7.jpg 2.4 ± 0.3 4.8 ± 0.4 48.0 ± 4.3 3.7 ± 1.5 71 19

Abbreviations: CC50, 50% cytotoxic concentration; EBOV, Ebolavirus; IC50, 50% inhibitory concentration; MARV, Marburgvirus; SI, selectivity index. Data are means ± SD from at least two independent experiments.