Figure 2.

Phylogenetic analysis of lamprey Vav3 with Vav3, Vav2 and Vav1 homologs based on the neighbor-joining (NJ) method. The number at each node presents the percentage of bootstrapping after 1000 replications. Vav3, Vav2 and Vav1 homologs from lampreys, teleosts, amphibians, reptiles, birds, mammals and invertebrates are marked on the right side. The genetic distance is indicated by the ruler below the tree. The protein accession numbers not listed in Figure 1 are as follows: Ovisaries musimon-Vav3: XP_011979369; Orcinus orca-Vav3: XP_004263156; Ficedula albicollis-Vav3: XP_016155749; Pelodiscus sinensis-Vav3: XP_006119853; Xenopus tropicalis-vav3: XP_012817964; Esox lucius-Vav3: XP_010889475; Sturnus vulgaris-Vav3: XP_014740857.1; Aplysia californica-Vav3-like: XP_012934911; Biomphalaria glabrata-Vav2-like: XP_013065355; Esox lucius-Vav2: XP_010892236; Xenopus tropicalis-Vav2: NP_001039156; Pelodiscus sinensis-Vav2: XP_006123811; Ficedula albicollis-Vav2: XP_016157973; Orcinus orca-Vav2: XP_004285057; Ovisaries musimon-Vav2: XP_011973373; Sturnus vulgaris-Vav2: XP_014728763; Orcinus orca-Vav1: XP_004277328; Ovis aries-Vav1: XP_012034581; Homo sapiens-Vav1: NP_005419; Mus musculus-Vav1: NP_035821; Struthio camelus-vav1: XP_009668692; Pseudopodoces humilis-vav1: XP_014117547; Nipponia nippon-Vav1: XP_009465925; Alligator mississippiensis-Vav1: XP_006265667; Pelodiscus sinensis-Vav1: XP_006131759; Chelonia mydas-Vav1: XP_007070109; Xenopus tropicalis-Vav1: XP_002940062; Poecilia latipinna-Vav1: XP_014889433; Takifugu rubripes-Vav1: XP_011611118; and Hydra vulgaris-Vav1-like: CDG71338.