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. 2017 Sep 22;18(10):2039. doi: 10.3390/ijms18102039

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Decreased expression of ALDH1A1 reduces breast cancer cell proliferation, but adhesion and migration of human breast cancer cells is differentially influenced by ALDH1A1 versus ALDH1A3 in vitro. MDA-MB-468 (left panels) and SUM159 (right panels) human breast cancer cells were treated with control siRNA (siCON) or ALDH-specific siRNA (siALDH1A1 or siALDH1A3) for 96 h to generate the following cell lines: 468CON, 468ALDH1A1^low, 468ALDH1A3^low, 159CON, 159ALDH1A1^low, 159ALDH1A3^low. (A) Proliferation; (B) adhesion assays; (C) migration; and (D) colony formation. In all cases, data represents the mean ± SEM normalized to respective scrambled control. * = significantly different than respective scrambled control (p < 0.05).