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Structures of CXC chemokine CXCL8 (Interleukin-8, PDB access code 1IL8, [10]) (panel A) and CC chemokine CCL5 (RANTES, PDB access code 5COY, [17]) (panel B) are shown. Two orientations of the CXCL4 M2 tetramer structure (platelet factor-4, PF4; PDB access code 1PFM, [18]) are shown in panels (C,D). C-terminal helices are colored red, and the remaining sequences are colored cyan.
