Table 1.

Hub genes and oligodendrocyte-related genes that co-downregulate in spinal cord periplaques as compared to NAWM.

Hub Genes
LHPP	Phospholysine phosphohistidine inorganic pyrophosphate phosphatase
NDRG1	N-myc downstream regulated 1
PAQR6	Progestin and adipoQ receptor family member VI
PEA15	Phosphoprotein enriched in astrocytes 15
RASSF2	Ras association (RalGDS/AF-6) domain family member 2
Oligodendrocyte-Related Genes
NDRG1	N-myc downstream regulated 1
MOBP	Myelin-associated oligodendrocyte basic protein
MBP	Myelin basic protein
PLP1	Proteolipid protein 1
OLIG1	Oligodendrocyte transcription factor 1
SIRT2	Sirtuin (silent mating type information regulation 2 homolog) 2 (Saccharomyces cerevisiae)
FA2H	Fatty acid 2-hydroxylase

A co-expression network was generated with the set of genes that constantly downregulated in periplaques as compared to adjacent NAWM. In this co-expression module, hubs were defined as genes (nodes) being connected to at least half of the total number of genes (nodes) forming the network.