Table 3.
Subset of well-studied lncRNAs whose transcripts were significantly (p ≤ 0.01) differentially expressed (Diff. Exp.; up (+) or down (−) regulated) in primary human hepatocytes after exposure to 100 µM DEET, 10 µM fipronil, or a mixture of 100 µM DEET and 10 µM fipronil for 72 h.
| Diff. Exp. | Gene Symbol a | Gene Name b | FC c (DT) | FC c (Fip) | FC c (DT+Fip) |
|---|---|---|---|---|---|
| Up | H19 | Long Intergenic Non-Protein Coding RNA 8 | - | +1.55 | +0.59 |
| Down | HULC | Highly Up-Regulated In Liver Cancer | - | −0.57 | - |
| MALAT1 | Metastasis Associated Lung Adenocarcinoma Transcript 1 | −1.34 | −1.87 | −2.28 | |
| NEAT1 | Nuclear Enriched Abundant Transcript 1 | −1.10 | −1.22 | −1.52 | |
| XIST | X (Inactive)-Specific Transcript | - | −0.60 | −0.93 | |
| TSIX | TSIX Transcript, XIST Antisense RNA | - | −0.59 | −0.97 | |
| MEG3 | Maternally Expressed 3 | - | −1.19 | −1.70 |
a HUGO gene nomenclature committee (HGNC) gene symbol [35]; b National Center for Biotechnology Information (NCBI) gene description; c FC = log2 fold change; DT = 100 µM DEET; Fip = 10 µM fipronil; DT + Fip = 100 µM DEET plus 10 µM fipronil mixture.