Figure 3.

The multifunction of PARP1 in tumorigenesis. PARP1 is considered to promote tumor development potentially through many pathways. Briefly, PARP1 regulates gene transcription through interacting with transcription factors, transcription machinery, and chromatin modulators. Hyperactivated PARP1 upregulates inflammatory signal factors in tumors. Also, PARP1 modulates cancer cellular life cycle via regulating cellular mitosis and cell death pathways, including apoptosis, necrosis, and necroptosis. PARP1 activates pro-angiogenic factors and induces angiogenesis and metastasis in tumors.