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. 2017 Oct 14;18(10):2143. doi: 10.3390/ijms18102143

Figure 1.

Figure 1

Behavioural test. Time course of the effect of different doses of melatonin (5 and 10 mg/kg) on thermal hyperalgesia evaluated as withdrawal latency to heat; this was measured by the plantar test on the right hind-paw and expressed in seconds (s). The administration of melatonin was performed as a single intraperitoneal injection at the 14th day after surgery, when the neuropathy was established. Sham-operated rats treated with 1% ethanol in saline (vehicle for melatonin) (SHAM + V); sham-operated rats treated with melatonin (10 mg/kg) (SHAM + MEL10); Chronic constriction injury (CCI) rats treated with 1% ethanol in saline (vehicle for melatonin) (CCI + V); CCI rats treated with melatonin (5 mg/kg) (CCI + MEL5); CCI rats treated with melatonin (10 mg/kg) (CCI + MEL10). Data represent means ± SEM, ° p < 0.05 vs. SHAM + V, * p < 0.05 vs. CCI + V, § p < 0.05 vs. CCI + MEL10.