Skip to main content
. 2017 Oct 14;18(10):2143. doi: 10.3390/ijms18102143

Figure 5.

Figure 5

nNOS and iNOS evaluation in plantar skin. (a) Quantitative evaluation of nNOS immunopositivity in the epidermis of the right hind-paw plantar skin as IOD (integrated optical density) in the experimental animals: sham-operated rats treated with 1% ethanol in saline (vehicle for melatonin) (SHAM + V); sham-operated rats treated with melatonin 10 mg/kg (SHAM + MEL10); CCI rats treated with 1% ethanol in saline (vehicle for melatonin) (CCI + V); CCI rats treated with melatonin (5 mg/kg) (CCI + MEL5); CCI rats treated with melatonin (10 mg/kg) (CCI + MEL10). Data represent means ± SEM, ° p < 0.05 vs. SHAM + V, * p < 0.05 vs. SHAM + MEL10, # p < 0.05 vs. CCI + V. (b) Quantitative evaluation of iNOS immunopositivity in the epidermis of the right hind-paw plantar skin as IOD (integrated optical density) in the experimental animals: sham-operated rats treated with 1% ethanol in saline (vehicle for melatonin) (SHAM + V); sham-operated rats treated with melatonin 10 mg/kg (SHAM + MEL10); CCI rats treated with 1% ethanol in saline (vehicle for melatonin) (CCI + V); CCI rats treated with melatonin (5 mg/kg) (CCI + MEL5); CCI rats treated with melatonin (10 mg/kg) (CCI + MEL10). Data represent means ± SEM, ° p < 0.05 vs. SHAM + V, # p < 0.05 vs. CCI + V, § p < 0.05 vs. CCI + MEL5.