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Action and targeting of P-gp and MDR1 drug efflux pumps. Activation of MDR1/ABCB1 transcription leads to drug efflux and inhibition of cytochrome p450 isoenzymes. Chemosensitivity and cell death can be enhanced by inhibitors and siRNA targeted therapies. Abbreviations: adenosine triphosphate binding cassette-B1 (ABCB1) transporters; antisense oligonucleotide (ASO), cluster of differentiation 44 (CD44), multidrug resistance protein 1 (MDR1), small interfering RNA (siRNA).
