Table 1.
Protective effects of argan oil (AO) and olive oil (OO) against LPS (lipopolysaccharide)-induced dysregulation, in regard to plasmatic biochemical parameters.
| Plasma Parameters | Control | LPS | AO | AO + LPS | OO | OO + LPS |
|---|---|---|---|---|---|---|
| Glycaemia (mg/dL) | 2.91 ± 0.08 | 4.63 ± 0.6 ** | 2.28 ± 0.21 * | 3.7 ± 0.5 ** | 3.56 ± 0.23 * | 3.48 ± 0.39 ## |
| 100% | 159% a | 78.3% a | 80% b | 122% a | 75.2% b | |
| Cholesterol (mg/dL) | 1.97 ± 0.11 | 2.33 ± 0.28* | 1.96 ± 0.13 | 2.07 ± 0.06 | 1.66 ± 0.15 * | 1.02 ± 0.03 ***## |
| 100% | 118% a | 99.5% a | 88.8% b | 84.3% a | 43.8% b | |
| Proteins (mg/dL) | 48.17 ± 7.89 | 68.15 ± 12.8 * | 42.60 ± 2.67 | 45.75 ± 0.9 # | 51.83 ± 5.8 | 38.80 ± 3.39 # |
| 100% | 141% a | 88.4% a | 67.1% b | 107.6% a | 56.9% b | |
| Uremia (mmol/dL) | 6.35 ± 0.07 | 23.17±2.29 *** | 6.6 ± 0.36 | 19.18 ±1.18 ***# | 4.80 ± 0.99 | 16.95 ± 0.07 ***## |
| 100% | 365% a | 104% a | 82.8% b | 75.6% a | 73.15% b | |
| AST (U/mL) | 395.5 ± 7.78 | 480.8 ± 11.6 *** | 387.1 ± 0.71 | 295 ± 8.49 ***### | 329.95 ± 13.79 ** | 292 ± 16.97 ***### |
| 100% | 121.6% a | 97.9% a | 61.4% b | 83.4% a | 60.7% b | |
| ALT (U/mL) | 43.45 ± 2.19 | 72.9 ± 1.56 *** | 63.03 ± 1.78 *** | 47.3 ± 5.80 ### | 37.9 ± 3.96 | 48.05 ± 10.11 ## |
| 100% | 167.8% a | 145% a | 64.9% b | 87.2% a | 65.9% b | |
| ALT to AST % increase ratio | 1 | 1.38 | 1.48 | 1.05 | 1.05 | 1.09 |
All values are means ± SEM (n = 6/group). Statistical significance of higher mean signal intensity (*** p < 0.001, ** p < 0.01, * p < 0.05) compared to control and (### p < 0.001, ## p < 0.01, # p < 0.05) compared to LPS. Fold change in percent was calculated for each group by dividing the mean of the LPS group, AO group or OO group per mean of the control group (a) and by dividing the mean of the AO + LPS group or OO + LPS group per mean of the LPS group (b). AST: aspartate transaminase; ALT: alanine aminotransferase.