Table 2.
The prognostic factors for recurrence and progression in 71 NMIBC patients treated with BCG.
| Variables | N | Intravesical Recurrence-Free Survival | Progression-Free Survival | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate † | Univariate | Multivariate † | ||||||||||
| HR | 95% CI | p Value | HR | 95% CI | p Value | HR | 95% CI | p Value | HR | 95% CI | p Value | ||
| Sex | |||||||||||||
| Male | 63 (89%) | 1 | 1 | ||||||||||
| Female | 8 (11%) | 0.64 | 0.24–1.72 | 0.52 | NA | 1.24 | 0.25–6.21 | 0.98 | NA | ||||
| Age | |||||||||||||
| ≤70 | 37 (52%) | 1 | 1 | ||||||||||
| >70 | 34 (48%) | 1.05 | 0.56–1.97 | 0.91 | NA | 1.88 | 0.73–4.86 | 0.22 | NA | ||||
| T stage | |||||||||||||
| Ta or isolated Tis | 30 (42%) | 1 | 1 | ||||||||||
| T1 | 41 (58%) | 1.20 | 0.64–2.26 | 0.69 | NA | 1.29 | 0.49–3.40 | 0.81 | NA | ||||
| Tumor grade | |||||||||||||
| Low | 13 (18%) | 1 | 1 | 1 | |||||||||
| High | 58 (82%) | 0.68 | 0.26–0.96 | 0.04 | 0.81 | 0.24–1.16 | 0.10 | 1.85 | 0.56–6.09 | 0.48 | NA | ||
| Multiplicity | |||||||||||||
| Single | 38 (54%) | 1 | 1 | ||||||||||
| Multiple | 33 (46%) | 0.74 | 0.39–1.39 | 0.78 | NA | 1.20 | 0.46–3.15 | 0.46 | NA | ||||
| Tumor size | |||||||||||||
| <3 cm | 52 (73%) | 1 | 1 | ||||||||||
| ≥3 cm | 19 (27%) | 0.76 | 0.38–1.52 | 0.58 | NA | 1.05 | 0.39–2.87 | 0.89 | NA | ||||
| Concomitant CIS | |||||||||||||
| No | 22 (31%) | 1 | 1 | ||||||||||
| Yes | 49 (69%) | 0.48 | 0.24–1.06 | 0.097 | NA | 2.48 | 0.91–6.74 | 0.14 | NA | ||||
| Treg | |||||||||||||
| Low | 31 (44%) | 1 | 1 | 1 | 1 | ||||||||
| High | 40 (56%) | 2.53 | 1.32–4.86 | 0.001 | 3.07 | 1.55–6.07 | 0.001 | 3.38 | 1.29–8.88 | 0.027 | 3.43 | 1.20–9.74 | 0.021 |
| TAM | |||||||||||||
| Low | 35 (49%) | 1 | 1 | 1 | 1 | ||||||||
| High | 36 (51%) | 2.31 | 1.27–4.30 | 0.029 | 1.39 | 0.68–2.84 | 0.37 | 3.35 | 1.29–8.66 | 0.052 | 2.50 | 0.79–8.02 | 0.12 |
| IL6+ UC cells | |||||||||||||
| Low | 32 (45%) | 1 | 1 | ||||||||||
| High | 39 (55%) | 1.36 | 0.73–2.56 | 0.22 | NA | 1.39 | 0.53–3.61 | 0.54 | NA | ||||
NMIBC, non-muscle invasive bladder cancer; BCG, Bacillus Calmette-Guerin; HR, hazard ratio; CI, confidence interval; CIS, Carcinoma in situ; Treg, regulatory T cell; TAM, Tumor-associated macrophage; UC, urothelial carcinoma; † Multivariate Cox regression analysis; NA, not analyzed.