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Regulation of the MDM2-signaling network by the pro-survival kinase AKT. AKT-mediated phosphorylation of Mdm2 promotes Mdm2 entry into the nucleus and enhances its ubiquitination-promoting function which leads to p53 inactivation, inhibition of apoptosis, and increased survival. Phosphorylation of MDMX by AKT stabilizes MDM2 E3-ligase activity.
