Table 2.

MDM2 regulators and functional outcome [45,53,69,73,74,75,76,77,78,79,80].

Effectors of MDM2	Effect on MDM2 Function
PTEN	Transcriptional inhibition
NF-κB	Transcriptional activation
Raf	Transcriptional activation
Smad3/4	Transcriptional activation
E2F1	Transcriptional inhibition
ATM	MDM2 phosphorylation at S394 and/or S395 is required for p53 accumulation, stabilization and activation
c-AbI	Tyrosine phosphorylation of MDM2 facilitates MDM2-MDMX complex formation and regulates p53 stabilization
AKT	Phosphorylation of MDM2 at residues S166 and S188 inhibits its self-ubiquitination and at S186 Akt enhances the ubiquitination-promoting function of MDM2 which results in reduction of p53 protein
Daxx	Stabilizes; enhances interaction between Mdm2 & Hausp
Cyclin G	Dephosphorylation of Mdm2
MdmX	Inhibits auto-ubiquitination of MDM2 E3 ligase activity
Elf4/Mef	Transcriptional activation
p19ras	Blocks Mdm2-p73 interaction
Seladin-1	Blocks Mdm2-p53 interaction
RPS3/S7/S27	Blocks Mdm2-p53 interaction
L5/L11/L23/L26	Blocks Mdm2 ubiquitination of p53
p38	p300 binds to p53 and MDM2; there is evidence that p38 can phosphorylate p300 and increase capacity of MDM2 to promote p300 degradation.
Cyclin a-CDK complexes	phosphorylate MDM2 and affect interaction of MDM2 with proteins
p14ARF	E3 ligase inhibition in the context of MDM2-p53 interactionsE3 ligase activation in the context of MDM2-MDMX interactions
MTBP	Binds to MDM2 and Induces a G1 Arrest

PTEN = phosphatase and tensin homolog; NF-κB = nuclear factor κ-light-chain-enhancer of activated B cells; AKT = Protein kinase B is a serine/threonine-specific protein kinase; MTBP = MDM2-binding protein.