Table 2.

IC₅₀ values for signaling molecules in humans.

Signaling Molecule	IC50	Reference
PTPRB	98 pM	[114]
PTEN	0.6 nM	[76]
PTP1B	3–17 nM	[100]
SHP-1	92 nM	[115]
SHP-2	1–2 µM	[100]
TC PTP	200 mM	[99]
Calcineurin	250 nM–7 µM	[116]
Ca-dependent endonuclease	1 µM (in the presence of 10 µM Ca)	[117]
LAR	20 µM	[100]
PDE4A	>5 µM	[118]
PDE 5	>1 µM	[119]
PDE 6	>1 µM	[120]
IKK	8.7 µM	[121]
Caspase 3	<10 nM, 100 nM	[86,99]

PTPRB: Protein phosphotyrosylphosphatase receptor type B; PTEN: Phosphatase and tensin homologue deleted on chromosome 10; PTP1B: Protein phosphotyrosylphosphatase 1B; SHP: SH2-containing phosphatase; TC PTP: T cell PTP; LAR: Leukocyte common antigen-related protein; PDE: phosphodiesterase; IKK: IκB kinase.