Scheme 3. Scope of the enantioselective cyclopropanecarboxamide cyclization. Reaction conditions: 1 (0.10 mmol), Cs2CO3 (0.15 mmol), Pd(dba)2 (2.00 μmol), L2 (4.00 μmol), PivOH (30 μmol), 0.30 M in mesitylene at 130 °C for 12 h. Yields of isolated products 2; er's determined by HPLC with a chiral stationary phase. a [(η3-cinnamyl)Pd(Cp)] instead of Pd(dba)2. b With Cs2CO3 (0.20 mmol), Pd(dba)2 (10.0 μmol), L2 (20.0 μmol), PivOH (50 μmol).
