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. 2015 Jun 17;6(9):5164–5171. doi: 10.1039/c5sc01909e

Table 1. Influence of the ligand on the product distribution a .

Inline graphic
Entry L 4a b (%) 15 b (%) 14a b (%) 14b b (%)
1 tBu3P 4 <1 59 21
2 PCy3 58 30 8
3 PPh3 40 40 11
4 L2 63 33 <1
5 L3 12 40 28 8

aReaction conditions: 0.05 mmol 3a, 2.5 mol% Pd(dba)2, 5.0 mol% L, 20 mol% AdCO2H, 1.5 equiv. Cs2CO3 0.25 M in toluene, 110 °C, 12 h.

bDetermined by 1H-NMR with an internal standard.