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. 2017 Mar 6;4(2):152–160. doi: 10.1002/ams2.265

Table 6.

Proposed mechanism of chronic toxicity of local anesthetics on nerve fibers

Effects on nerve cell body: membrane lysis, apoptosis
Effects on nerve fibers: electrophysiological effects, delay in axonal transport
Effects on edge of growing nerve fibers: growth cone collapse