Figure 3.

Cy5-SPNs accumulation within the intestine of DSS-induced mouse models of colitis. A. Representative near-infrared fluorescent (NIRF) in vivo image of Cy5-SPNs accumulating within the abdominal area in mice administered with DSS for 5, 7 and 10 days. 6 mg of PLGA based Cy5-SPNs were i.v injected. B. Normalized NIRF signal intensities from the in vivo images. C. Ex vivo colon NIRF imaging and length. D. Body weight variation over time of mice administered with DSS. Results are presented as mean ± SD (n=5/group). * P < 0.05; ** P < 0.01; *** P < 0.001