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. 2017 Aug 29;7(15):3715–3731. doi: 10.7150/thno.19678

Figure 3.

Figure 3

Human and mouse vessels relax in response to SE175 ex vivo [A, D] C57BL/6J mouse uterine arteries, [B, E] human term placental chorionic plate arteries, and [C] eNOS-/- mouse uterine arteries were collected, the arteries dissected and mounted onto a wire myograph. Vessels were pre-constricted with phenylephrine and vessel relaxation to [A - C] free or [D, E] liposomally-encapsulated SE175 was recorded. [A, B] Dose-dependent relaxation; [C-E] time-dependent relaxation to 10-5 M SE175. SE175 (black circles, n = 6), DMSO (blue squares, n = 6), time control (no treatment; red triangles, n = 6). Mean ± SEM; error bars not visible if smaller than symbol. Dose response curves were compared using two-way ANOVA with Bonferroni's post hoc test. **P<0.001, ***P<0.0008, ****P<0.0001.