Table 1.
Differential expression of mRNAs in brains from SPG21−/− compared to SPG21+/+ mice
| GenBank accession # | Symbol | Gene/protein name | Fold change | p |
|---|---|---|---|---|
| 6 months | ||||
| NM_008142 | Gnb1 | Guanine nucleotide binding protein beta 1 | −1.79 | 0.007 |
| NR_001585 | Speer7-ps1 | Spermatogenesis associated glutamate-rich protein 7, pseudogene 1 | −1.64 | 0.027 |
| NM_133347 | Dhx30 | DEAH box polypeptide 30 | −1.63 | 0.004 |
| NM_022420 | Gprc5b | G-protein coupled receptor, family C, group 5, member b | −1.62 | <0.001 |
| NM_176849 | Arglu1 | Arginine and glutamate rich 1 | −1.59 | 0.027 |
| XM_620516 | Rkhd3 | Ring finger and KH domain containing 3 | −1.54 | 0.036 |
| NM_013790 | Abcc5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 1.72 | 0.045 |
| NM_019698 | Aldh18A1 | Aldehyde dehydrogenase family 18, member A1 | 1.66 | 0.024 |
| NM_010380 | H2-D1 | Histocompatibility 2, D region locus 1 | 1.55 | 0.020 |
| BC052465 | D12Ertd553e | DNA segment, ERATO Doi 553, expressed, mRNA | 1.54 | 0.032 |
| NM_011671 | Ucp2 | Uncoupling protein 2 | 1.52 | 0.042 |
| NM_030689 | Nptxr | Neuronal pentraxin receptor | 1.50 | 0.048 |
| 15 months | ||||
| NM_025287 | Spop | Speckle-type POZ protein | −1.58 | 0.049 |
| NM_021560 | Bhlhb5 | Basic helix-loop-helix family, member e22 | −1.52 | 0.031 |
| NM_011464 | Spint2 | Serine protease inhibitor, Kunitz type 2 | −1.52 | 0.003 |
| NM_008448 | Kif5b | Kinesin family member 5B | 2.70 | 0.010 |
| NM_009009 | Rad21 | RAD21 homolog (Schizosaccharomyces pombe) | 2.21 | 0.027 |
| NM_009703 | Araf | v-raf murine sarcoma 3611 viral oncogene homolog | 1.90 | 0.043 |
| NM_025827 | Lonp2 | Lon peptidase 2, peroxisomal | 1.85 | 0.024 |
| NM_026030 | Eif2s2 | Eukaryotic translation initiation factor 2, subunit 2 (beta) | 1.78 | 0.040 |
| NM_001099631 | Sh2d5 | SH2 domain containing 5 | 1.77 | 0.042 |