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. Author manuscript; available in PMC: 2017 Nov 2.
Published in final edited form as: J Alzheimers Dis. 2017;56(3):1037–1054. doi: 10.3233/JAD-160524

Fig. 4. Association of rs2228145 in IL6R with earlier age of AD onset in APOE4 carriers.

Fig. 4

(A) The IL6R risk allele discovered in our modifier screen changes the 358th amino acid in IL-6R from D to A. This amino acid lies at the cleavage site for IL-6R. Box = transmembrane spanning residues. (B) Summary of association at rs2228145 in the five datasets. The case and controls frequencies are those of the minor allele “C”.