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. 2017 Aug 29;7(16):3856–3872. doi: 10.7150/thno.19981

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FKBP-ELP carrier protects against tissue necrosis during SC administration. (a) After the conclusion of 50 days of SC treatment three times weekly at 0.75 mg/kg Rapa dose, skin sections from the most recent site of injection were excised, paraffin embedded, and evaluated for H & E histopathology. Free Rapa treatment was toxic at site of injection compared to Rapa-loaded FKBP-ELPs. Panels i, ii, iii, iv, and v are from a representative mouse treated with PBS, free Rapa, FAF-Rapa, FA-Rapa and FSI-Rapa respectively (n = 6-8). (b) The relative differences between the SC toxicity of these formulations at the site of injection was also externally evident on day 30 of this study.