Figure 6.

Enforcement of miR-194 expression sensitized HCT116 to chemotherapy. Cells with stable miR-194 overexpression were subjected to (A) oxaliplatin and (B) irinotecan to measure their sensitivity. Cells were treated for 72 h and their viability was assessed by MTS assay and normalized to the absorbance of a DMSO treated control for each cell clone. ** P < 0.01 and *** P < 0.001 show the differences from vehicle control for HCT116^ZsGreen1 cells, while ^### P < 0.001 indicates differences from vehicle control for HCT116^{ZsGreen1-miR-194} cells.