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. 2017 Sep 5;7(16):3901–3914. doi: 10.7150/thno.20190

Figure 6.

Figure 6

Toxicity analysis of PPNs in vivo. (A) Body weight changes of SKOV-3 tumor-bearing mice after intravenously treated with various DOX formulations (DOX=2.5 mg/kg, PPNs=2 mg/kg calculate on porphyrin) with or without light irradiation (n=6). (B) Blood cell counts and serum chemistry of mice with intravenous administration of PPNs or PBS at day 5 after the last dosage (mean ± SD, n=3). (C) Representative H&E stained images of major organs from mice in PBS control group and PPNs-DOX administrated (2 mg/kg, calculated on porphyrin) at day 50 after SKOV-3 injection.