Figure 1.

Assessing the impact of targeted GNP on radioenhancement. A. A sample was taken from the tumor of a patient with adenoid cystic carcinoma (ACC) of the parotid gland. B. Molecular profiling was performed on the tumor, identifying a target mutation, anaplastic lymphoma kinase. Gold nanoparticles (GNP) were prepared and coated with crizotinib, a tyrosine kinase inhibitor. C. 50 µl human ACC were subcutaneously injected into the back flank area of a nude mouse. D. Actively targeted GNP were injected to the tail vein of the mouse and E. accumulated at the tumor. F. Twelve hours post injection the mouse was irradiated once, and the tumor size was closely evaluated in vivo using micro CT and measurements.