Figure 4.

Imaging of the tumor with 3D whole-body volume rendering CT on day two. Scans of mice were performed with nominal resolution (pixel size) of 36 m, employing an aluminum filter 0.2 mm thick and an applied X-ray tube voltage of 45 kV. Surface-rendered 3D models were constructed for 3D viewing of the analyzed mice. (A) In the control group, the tumor is barely detected (left panel), while in the targeted GNP group (B) the tumor is easily observed by the gold accumulation (yellow dots; left panel). The GNP can also be seen as white dots in the tumor (right panel, black and white 3D volume CT image). Arrow indicates the tumor in all panels.