Figure 1.
PNP and post-FUS gadolinium enhancement for each sonication scheme. (A) PNP for schemes 1 and 3 were calibrated based on acoustic emissions. No significant difference was detected (scheme 1: 0.192 MPa ± 0.020 MPa; scheme 3: 0.201 MPa ± 0.015 MPa; p = 0.460). PNP for scheme 2 was set at 0.290 MPa. (B) Post-FUS gadolinium enhancement was assessed at each target by quantifying mean voxel intensity relative to the non-sonicated control area in each animal. Schemes 2 and 3 both resulted in a significantly greater degree of enhancement than scheme 1 (scheme 1: 1.46 ± 0.44; scheme 2: 2.52 ± 0.47; scheme 3: 2.23 ± 0.34 vs). *** indicates p < 0.01; n = 8 for each sonication scheme.