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. 2017 Sep 20;7(16):4001–4012. doi: 10.7150/thno.18788

Figure 2.

Figure 2

Ginsenoside Rg1 inhibited hepatic G6Pase and PEPCK expression. (A, B) mice fed the indicated diet for 8 weeks (n=10/group). Liver mRNA levels of G6Pase and PEPCK were determined by quantitative RT-PCR; (C, D) G6Pase and PEPCK protein expressions in the liver of chow or HFD-fed mice were determined by western blot; (E, F) Chow-fed mice were orally administered Rg1 or Met, and then intraperitoneally injected with glucagon (2 mg/kg). G6Pase and PEPCK mRNA expressions in liver were determined by qPCR. Rg1, 50 mg/kg; Met: metformin, 200 mg/kg. Data are shown as the mean ± SEM after normalization to the control (n=6/group). *p < 0.05, vs. chow or control; #p < 0.05 vs. HFD or control. The difference was determined using Wilcoxon rank test.