Table 3.
Differential expression of genes from injured lung tissue in comparison control non-injured lung tissue
| Accession No. | Gene Symbol | Gene Name | Molecular Function | Fold Change |
|---|---|---|---|---|
| NM_001047130 | IL2 | Interleukin 2 | T-cell activation and proliferation, B-cell, NK cell, and monocyte activation | 7798.12 |
| XM_001093307 | SPP1 | Secreted phosphoprotein 1 | Upregulation of inflammatory cytokines including IL-12 and Interferon Gamma | 1139.76 |
| XM_001110657 | CXCL14 | Chemokine (C-X-C motif) ligand 14 | Chemotactic for monocytes | 382.36 |
| MIP-2γ | ||||
| XM_001095645 | MAL | Mal, T-cell differentiation protein | Endoplasmic reticulum protein likely associated with T-cell signal transduction | 257.02 |
| XM_001103106 | PRG3 | Proteoglycan 3 | Stimulates neutrophil respiratory burst and IL-8 production, as well as basophil histamine and leukotriene C4 production. | 202.97 |
| XM_001101685 | KNG1 | Kininogen 1 | Part of kallikrein blood coagulation and can be cleaved to produce bradykinin | 86.68 |
| XM_001092700 | FGF10 | Fibroblast growth factor 10 | Involved in wound healing, and secreased by alveolar epithelial cells in response to injury. | 81.64 |
| XM_001094451 | LBP | Lipopolysaccharide binding protein | Acute phase reactant to gram-negative bacteria and facilitates LPS binding to CD14 on monocytes. | 63.00 |
| XM_001108113 | IFNW1 | Interferon, omega 1 | Involved in Toll-Like receptor Signaling Pathways and Type I interferon receptor binding. | 47.27 |
| XR_092351 | LOC100426120 | BCL2/adenovirus E18 19 kDa protein interacting protein 3-like | BCL2 – Suppresses apoptosis by regulating mitochondrial membrane permeability and inhibits caspase activity. | 46.51 |
| XM_001112015 | LTA | Lymphotoxin alpha (TNF superfamily, member 1) | Member of TNF family and mediates various inflammatory, immunostimulatory, and antiviral responses. | 31.78 |
| XM_001100604 | BNIP2 | BCL2/adenovirus E1B 19kDa interacting protein 2 | Inhibits cell death | 31.56 |
| XM_001110285 | BCL2L1 | BCL2-like 1 | Regulates mitochondrial release of apoptotic factors | 15.07 |
| NM_001032946 | CCL23 | Chemokine (C-C motif) ligand 23 | Potent chemotactic factor for monocytes, resting T-cells, and neutrophils. | 23.81 |
| MIP-3 | ||||
| XM_001107576 | IFNA14 | Interferon, alpha 14 | Binds type interferon receptor and demonstrates anti-viral activity | 19.58 |
| XM_001107510 | IL1R1 | Interleukin 1 receptor, type I | Mediates IL-1 dependent activation of NF-kappa-B and MAPK pathways. | 18.46 |
| XM_001087874 | LOC699418 | Eosinophil lysophospholipase-like | Protecgt eosinophils from being lysed by large amounts of phospholipids | 15.98 |
| XM_001117159 | IL22 | Interleukin 22 | Part of IL-10 family and initiates innate immune responses against bacteria in gut and respiratory epithelial cells. | 14.93 |
| XM_001110530 | S100A8 | S100 calcium binding protein A8 | Involved in cell cycle progression and differentiation intracellularly as well as neutrophil chemotaxis, proinflammatory, pro-apoptotic, DAMP, and oxidant-scavening | 12.67 |
| XM_001108108 | IL18RAP | Interleukin 18 receptor accessory protein | Enhances IL-18R signaling though PEDF induced signaling. | 12.31 |
| XM_00108022 | PROK2 | Prokineticin 2 | Involved in circadian rhythm and gastrointestinal smooth muscle contraction. | 10.89 |
| XM_001113239 | IL22RA1 | Interleukin 22 receptor, alpha 1 | Part of IL-10 receptor complex and induces JAK/STAT pathways as well as anti-angiogenic activity. | 10.09 |
| XM_001096915 | TNFRSF11B | Tumor necrosis factor receptor superfamily, member 11b | TNF receptor family inhibits apoptosis as decoy receptor for TRAIL. | 9.86 |
| XM_001082859 | CASP9 | Caspase 9, apoptosis-related cysteine peptidase | Pro-apoptotic by through activation of caspase cascade. | 9.61 |
| NM_001042733 | IL6 | Interleukin 6 (interferon, beta 2) | Pluripotent cytokine which is anti-apoptotic and pro-inflammatory in acute phase response | 9.28 |
| XM_001104328 | ADORA1 | Adenosine A1 receptor | Adenosine receptor inhibits adenylyl cyclase | 9.27 |
| XM_001085850 | BCL2L10 | BCL2-like 10 (apoptosis facilitator) | Inhibits apoptosis by preventing mitochondrial cytochrome C release. | 8.33 |
| NM_001032875 | CCL20 | Chemokine (C-C motif) ligand 20 | Chemotaxis of dendritic cells, T-cells, and B-cells. | 7.60 |
| MIP-3α | ||||
| XM_001083110 | PXMP2 | Peroxisomal membrane protein 2, 22kDa | Pore-forming activity in peroxisomal membrane | 6.54 |
| XM_001108040 | BIK | BCL2-interacting killer (apoptosis-inducing) | Accelerates apoptosis | 5.34 |
| XM_001117272 | LOC721200 | Complement component 4A (Rodgers blood group) | Essential for the propagation of classical complement pathway and plays and major role infection diseases and inflammatory processes | 5.09 |
| XM_001118232 | TNFRSF1A | Tumor necrosis factor receptor superfamily, member 1A | Primary receptor for TNFa and pro-apoptotic. | 5.01 |
| NM_001142873 | MYC | V-myc myelocytomatosis viral oncogene homolog (avian) | Cell cycle progression and pro-apoptotic | 4.97 |
| NM_001047134 | IL1R2 | Interleukin 1 receptor, type II | Acts as decoy receptor for IL-1 and inhibits the activity of IL-1R1 ligands. | 4.93 |
| XM_001082504 | IL17RB | Interleukin 17 receptor B | Induces production of IL-8 | 4.67 |
| XM_001112911 | TYMP | Thymidine phosphorylase | Promotes angiogenesis by proliferation of endothelial cells. | 4.60 |
| XM_001086840 | APAF1 | Apoptotic peptidase activating factor 1 | Promotes apoptosis by binding cytochrome C and activates caspase cascade. | 4.53 |
| XM_001104160 | BAG3 | BCL2-associated athanogene 3 | Anti-apoptotic and binds HSP70/HSC70. | 4.36 |
| XM_001107790 | TNFRSF10A | Tumor necrosis factor receptor superfamily, member 10a | Receptor for TRAIL and induces apoptosis. | 4.29 |
| XM_001090833 | CASP7 | Caspase 7, apoptosis-related cysteine peptidase | Induces apoptosis | 4.20 |
| XM_001093641 | IL-1F5 | Interleukin 36 receptor antagonist | Inhibits NK-kB activation and prevents IL-36R signaling, and may activate anti-inflammatory pathway | 4.05 |
| XM_001109281 | BCL2A1 | BCL2-related protein A1 | Inhibits apoptosis | 3.86 |
| XM_001091119 | IL1F8 | Interleukin 36, beta | Pro-inflammatory signaling through IL-1RL2 and IL-36R, present in epithelial barrers, and stimulates production of IL-6 and IL-8 and various chemokines. | 3.85 |
| XM_001100700 | BLNK | B-cell linker | Involved in B-cell receptor signaling and activation of ERK/EPHB2, MAP, p38, AP1, NF-kB, and PLCG1 and 2 activation. | 3.78 |
| XM_001084983 | DAPK1 | Death-associated protein kinase 1 | Mediates IFNg signaled cell death | 3.59 |
| XM_001099305 | MGLL | Monoglyceride lipase | Metabolizes free fatty acids and glycerol, contributes to endocannabinoid signaling. | 3.56 |
| XM_001090430 | ERBB2 | V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | Part of epidermal growth factor receptor family and enhances activation of MAP-K and PI3K signaling pathways. | 3.55 |
| NM_001032917 | IL2RA | Interleukin 2 receptor, alpha | Part of IL-2 receptor family involved in mediating immune tolerance through regulatory T-cell activity. | 3.50 |
| XM_001092296 | LEFTY2 | Left-right determination factor 2 | TGF-beta receptor ligand and activates SMAD signaling pathway. | 3.14 |
| XM_001090570 | BAK1 | BCL2-antagonist/ killer 1 | Mediates mitochondrial release of cytochrome C and accelerates apoptosis. | 3.30 |
| XM_001089600 | MAPK1 | Mitogen-activated protein kinase 1 | MAP kinase signaling transduction pathway involved in cell growth, adhesion, survival, and differentiation. | 3.04 |
| XM_001086237 | BCL2L11 | BCL2-like 11 (apoptosis facilitator) | Induces apoptosis through caspase mediated pathway | 3.01 |
| XM_001095097 | CSF3 | Colony stimulating factor 3 (granulocyte) | Granulocyte stimulating factor involved in production, differentiation, and function of Granulocytes. | 3.00 |
| G-CSF | ||||
| NM_001032846 | IL7 | Interleukin 7 | Pro-inflammatory cytokine involved in both B-cell differentiation and Th1 response. | 2.96 |
| XM_001117239 | CRP | C-reactive protein, pentraxin-related | Acute phase reactant, part of pentaxin family and involved in agglutination, bacterial capsular swellilng, complement fixation, and phagocytosis. | 2.83 |
| XM_001104958 | IFNK | Interferon, kappa | Type I interferon family and regulates immune cell function. | 2.81 |
| XM_001103515 | PTX3 | Pentraxin 3, long | Part of pentraxin protein family induced in inflammatory response and promotes fibrocyte differentiation, and involved in regulating inflammation and complement activation. | 2.76 |
| XM_001099255 | SERPINA1 | Serpin peptidase inhibitor, clade A (alpha-1 antiproteniase, antitrypsin), member 1 | Proteolytic activity against plasmin, thrombin, trypsin, chymotrypsin, plasminogen activation, and decreases coagulation time. | 2.72 |
| XM_001101015 | TNFSF18 | Tumor necrosis factor receptor superfamily, member 18 | Co-stimulator for T-cell activation and proliferation. | 2.68 |
| XM_001083745 | OSMR | Oncostatin M receptor | Involved in IL-31 signaling and activation of STAT pathway. | 2.62 |
| XM_001108593 | LIF-L | Leukemia inhibitory factor-like | Involved in cell death signaling pathway | 2.58 |
| XM_001100017 | CXCR5 | Chemokine (C-X-C motif) receptor 5 | Chemoattractant for B-cells | 2.56 |
| XM_001106071 | IL17B | Interleukin 17B | Pro-inflammatory and induces release of TNFa and IL-1b. | 2.52 |
| XM_001090729 | INHBB | Inhibin, beta B | Part of TGF-beta family and involved in PEDF induced signaling and TGF-beta signaling pathways. | 2.46 |
| XM_001083817 | PCGF2 | Polycomb group ring finger 2 | Negative regulatory of transcription for cell proliferation control, cytokines, chemokines, and chemokine receptors. | 2.45 |
| XM_001094967 | SELE | Selectin E | Expressed by activated endothelial cells and involved in leukocyte trafficking | 2.39 |
| XM_001109474 | EPHX2 | Epoxide hydrolase 2, cytoplasmic | Involved in xenobiotic metabolism | 2.30 |
| NM_001032915 | CXCL9 | Macrophage migration inhibitory factor (glycosylation-inhibiting factor) | Pro-inflammatory cytokine which counteracts effects of glucocorticoids, but also regulates regulate macrophage activity in host defense. | 2.29 |
| MIF | ||||
| XM_001088935 | CD70 | CD70 antigen-like | Induces proliferation in activated T-cells, and further increases T-cell activation. | 2.28 |
| XM_001115079 | RPL13A | Ribosomal protein L13A | Part of Gamma Interferon Inhibitor of Translocation complex functions to inhibit inflammatory response. | 2.17 |
| NM_001032821 | CCL2 | Chemokine (C-C motif) ligand 2 | Chemotactic for monocytes and basophils, and augments monocyte activity. | 2.17 |
| MCP-1 | ||||
| XM_001094589 | TRAP1 | TNF receptor-associated protein 1 | Encodes for heat shock proteins and interacts with TNF type I to regulate cellular stress response. | 2.13 |
| XM_001103121 | LOC718480 | Peptidoglycan recognition protein 1-like | Involved in TNF signaling pathway, also displays bactericidal activity toward Gram-positive and bacteriostatic activity activity toward Gram-positive. | 2.04 |
| PGLYRP | ||||
| XM_001112492 | LOC711637 | Regenerating islet-derived protein 3-gamma-like | Bactericidal and bacteriostatic activity towards Gram-negative | 0.25 |
| REG3G | ||||
| XM_001084526 | CX3CR1 | Chemokine (C-X3-C motif) receptor 1 | Binds CX3CL1 and mediates both adhesive and migratory functions. | 0.25 |
| XM_001088286 | HRH1 | Histamine receptor H1 | Mediates contraction of smooth muscle, and increases capillary permeability. | 0.25 |
| NM_001032848 | GREM1 | Gremlin 1 | Inhibits monocyte chemotaxis. | 0.23 |
| XM_001101077 | FIGF | C-fos induced growth factor (vascular endothelial growth factor D) | Promotes angiogenesis, lymphogenesis, and stimulates proliferation and migration of endothelial cells. | 0.21 |
| NM_001032950 | CXCL11 | Chemokine (C-X-C motif) ligand 11 | Induced by IFN gamma, and is chemotactic for activated T-cells by binding CXC receptor 3. | 0.21 |
| I-TAC | ||||
| XM_001088781 | FOS | FBJ murine osteosarcoma viral oncogene homolog | Involved in cell proliferation and differentiation. | 0.17 |
| XM_001093896 | IL23R | Interleukin 23 receptor | Mediates T-cell, NK cell, and myeloid cell stimulation. | 0.14 |
| XM_001104979 | LOC708837 | Similar to growth differentiation factor 9 precursor | A member of the transforming growth factor-β (TGF-β) superfamily,involved in ovarian folliculogenesis | 0.10 |
| XM_001084047 | CCR8 | Chemokine (C-C motif) receptor 8 | Involved in monocyte chemotaxis | 0.03 |