Fig. 8.

Comparison of differential algorithms on human DAA treatment experiment with sample-swop test. We generated 3 pairs of “genuine” and “mock” datasets with the 3 biological replicates from the control and DAA treatment MeRIP-Seq experiment. By fixing the percentage of DRMSs in the 3 “mock” datasets, we calculated the percentage of DRMSs in their corresponding “genuine” datasets at the same significance level. QNB outperforms the competing methods especially at high significance level. The exomePeak method and Bltest achieved almost the same performance