Fig. 5. Representative coronal brain autoradiograms obtained after injecting intracranial U87MG-Luc2 glioma bearing mice with (a) vehicle or (b) 1 mg kg–1 PK11195 followed by [18F]-AB5186 10 min later. Brains were harvested for sectioning 20 min after tracer injection. Black arrows indicate tumour hotspots. (c) Ratios of tumour to contralateral tissue optical densities in the vehicle (n = 4) and PK11195 (n = 4) pre-treatment cohorts (P = 0.0002). Error bars represent the standard error of mean.
