Fig. 6. Averaged PET images of a U87MG-Luc2 glioma bearing mouse brain following [18F]-AB5186 injection: (a) 0–40 min averaged, (b) 41–80 min averaged, and (c) 81–120 min averaged; 120 min dynamic scan. White arrows indicate tumour hotspots. The brain was defined using the skull following manual co-registration of the CT image with the PET image. (d) H&E staining showing location of the tumour which stains dark blue. (e) Time–activity curves of the tracer in the tumour and contralateral brain regions obtained from manually defined VOIs. (f) Tracer kinetics expressed as a ratio of the tumour to contralateral SUVs.
