Table 1. Binding affinity and physicochemical values of PK11195 1 and AB5186 6 .

Compound	K i a (nM)	P m b	K m b	%PPB c
PK11195 1	3.1 ± 1.5	0.7	229.4	91.5
AB5186 6	2.8 ± 0.8	0.5	154.3	89.7

^a K _i values are the mean ± the standard deviation of three independent experiments.

^bDetermined using immobilised artificial membrane (IAM) column.

^cDetermined using human serum albumin (HSA) coated column.